Plastikbausteine BPA und BPS stimulieren das frühe Nervenwachstum im Hypothalamus beim Zebrafisch

BPA und BPS sind zentrale Bausteine für u.a. Polykarbonat (u.a. CD-/DVD-Plastik), Epoxydharz (Araldit, Dosen- und Büchseninnenauskleidung), Flammschutzmittel und Thermodruckerpapier. BPS wird teilweise als «harmlosere Variante» von und Alternative zu BPA angepriesen. Jetzt schreiben aber Cassandra D. Kincha, Kingsley Ibhazehiebob, Joo-Hyun Jeongb, Hamid R. Habibia und Deborah M. Kurrasch von der University of Calgary heute in den PNAS unter dem Titel

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

Here we demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. Furthermore, our study is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally affects neurodevelopment. These findings suggest that BPA-free products are not necessarily safe and support a societal push to remove all structurally similar bisphenol analogues and other compounds with endocrine-disruptive activity from consumer goods. Our data here, combined with over a dozen physiological and behavioral human studies that begin to point to the prenatal period as a BPA window of vulnerability, suggest that pregnant mothers limit exposure to plastics and receipts.

Und weiter:

Strikingly, treatment of embryonic zebrafish with very low-dose BPA (0.0068 μM, 1,000-fold lower than the accepted human daily exposure) and bisphenol S (BPS), a common analog used in BPA-free products, resulted in 180% and 240% increases, respectively, in neuronal birth (neurogenesis) within the hypothalamus, a highly conserved brain region involved in hyperactivity. Furthermore, restricted BPA/BPS exposure specifically during the neurogenic window caused later hyperactive behaviors in zebrafish larvae. (…) Although human epidemiological results are still emerging, an association between high maternal urinary BPA during gestation and hyperactivity and other behavioral disturbances in the child has been suggested.

Wie darauf wohl die Plastikindustrie reagieren wird?

Der seit 2011 vom Parlament eingeforderte und vom Schweizerischen Bundesrat auf Ende 2013 versprochene BAG-Bericht zum Thema BPA ist übrigens noch immer nicht erschienen, soweit bekannt!